Osteoprotegerin: Osteo-Vascular Connection

Osteoprotegerin: osteo-vascular connection.

Osteoprotegerin and Vascular Calcification: Clinical and Prognostic Relevance.

Osteoprotegerin (OPG) is a key regulator in bone metabolism, that also has effect in vascular system. Studies suggest that osteoprotegerin is a critical arterial calcification inhibitor, and is released by endothelial cells as a protective mechanism for their survival in certain pathological conditions, such as diabetes mellitus, chronic kidney disease, and other metabolic disorders. That has b...

Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients

Background Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end...

Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.

BACKGROUND The role of osteoprotegerin in vascular disease is unclear. Recent observational studies show that serum osteoprotegerin levels are associated with the severity and progression of coronary artery disease, atherosclerosis, and vascular calcification in patients. However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification. ME...

Osteo-Arthritis

symptoms as especially connoting osteo-arthritis; and of these he directs especial attention to " increased velocity and tension of the heart's action." He states that " a steady pulse of much tension, varying from 90 to no, is tolerably common. The pulse quickens synchronously with the earliest objective signs of osteo-arthritis." We are sorry that no sphygmographic tracings are given, and tha...